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Expansion mutation within polyglutamine (polyQ) tract proteins is known to underlie a number of severe neurodegenerative disorders such as Huntington’s Disease and Spinocerebellar Ataxia. Using a bioinformatics approach, we have identi􀃕ed a novel protein, FAM171B, that contains a stretch of 14 consecutive glutamines. Using in situ hybridization and immunohistochemistry experiments, our data strongly suggests that FAM171B is widely expressed in the brain with abundant expression in the hippocampus, cortex, and cerebellum. To begin elucidating FAM171B sub-cellular location we are using confocal 􀃖uorescence imaging of GFP-fusion tagged FAM171B and anti-FAM171B antibodies in vitro. Our 􀃕ndings indicate that FAM171B displays a punctate/vesicular staining pattern throughout the cytoplasm of human glioblastoma tissue culture cells and primary mouse cortical neurons. FAM171B localization is particularly enriched in the peri-nuclear region and adjacent to the plasma membrane. Current studies are utilizing organelle speci􀃕c markers to verify sub-cellular locale and live-cell imaging to assay whether FAM171B may tra􀃞c between intracellular compartments. 

Abstract With the establishment and maturation of the experimental programs searching for new physics with sizeable couplings at the LHC, there is an increasing interest in the broader particle and astrophysics community for exploring the physics of light and feebly-interacting particles as a paradigm complementary to a New Physics sector at the TeV scale and beyond. FIPs 2020 has been the first workshop fully dedicated to the physics of feebly-interacting particles and was held virtually from 31 August to 4 September 2020. The workshop has gathered together experts from collider, beam dump, fixed target experiments, as well as from astrophysics, axions/ALPs searches, current/future neutrino experiments, and dark matter direct detection communities to discuss progress in experimental searches and underlying theory models for FIPs physics, and to enhance the cross-fertilisation across different fields. FIPs 2020 has been complemented by the topical workshop “Physics Beyond Colliders meets theory”, held at CERN from 7 June to 9 June 2020. This document presents the summary of the talks presented at the workshops and the outcome of the subsequent discussions held immediately after. It aims to provide a clear picture of this blooming field and proposes a few recommendations for the next round of experimental results. 

A search for pair production of squarks or gluinos decaying via sleptons or weak bosons is reported. The search targets a final state with exactly two leptons with same-sign electric charge or at least three leptons without any charge requirement. The analysed data set corresponds to an integrated luminosity of 139 fb⁻¹of proton-proton collisions collected at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Multiple signal regions are defined, targeting several SUSY simplified models yielding the desired final states. A single control region is used to constrain the normalisation of theWZ+ jets background. No significant excess of events over the Standard Model expectation is observed. The results are interpreted in the context of several supersymmetric models featuring R-parity conservation or R-parity violation, yielding exclusion limits surpassing those from previous searches. In models considering gluino (squark) pair production, gluino (squark) masses up to 2.2 (1.7) TeV are excluded at 95% confidence level.